even if i am using a hotspot device (mifi)?
The OBiWiFi is completely dependent on 1) adequate IP packet transmission performance between the hotspot device and the internet and 2) adequate IP packet transmission between the hotspot device and the OBiWIFI.
The second of those should not be a problem as all the factors influencing it are completely under your control.
My answer to your initial question was from the standpoint that the OBi ATA sends and expects to receive exactly the same audio data in the same IP packets irrespective of being connected by OBiWIFI or ethernet cable.